Oxaliplatin For Colorectal Cancer Cure Drugs 61825-94-3 GMP API
|Synonyms:||Eloxatin;1-OHP;(1R,2R)-cyclohexane-1,2-diamine; oxalic acid;
platinum(+2) cation;Eloxatin (TN);Trans-l-diaminocyclohexane
|Appearance:||White crystalline solid|
Find out what oxaliplatin is, how you have it and other important
information about having this chemotherapy drug.
Oxaliplatin is an anti-cancer ("antineoplastic" or "cytotoxic")
chemotherapy drug. Oxaliplatin is classified as an "alkylating
Oxaliplatin is also called Eloxatin. It’s a treatment for different
types of cancer.
Oxaliplatin Is Used For
Oxaliplatin is used to treat colon or rectal cancer that has spread
(metastasized), it is often given in combination with other
anticancer drugs (fluorouracil and leucovorin).
Note: If a drug has been approved for one use, physicians sometimes
elect to use this same drug for other problems if they believe it
might be helpful.
Oxaliplatin Is Given
- It is given by infusion into the vein (intravenous, IV).
- There is no pill form of Oxaliplatin.
- The amount of Oxaliplatin you will receive depends on many factors,
including your height and weight, your general health or other
health problems, and the type of cancer you have. Your doctor will
determine your dosage and schedule.
DOSAGE AND ADMINISTRATION
ELOXATIN (oxaliplatin injection) should be administered under the
supervision of a qualified physician experienced in the use of
cancer chemotherapeutic agents. Appropriate management of therapy
and complications is possible only when adequate diagnostic and
treatment facilities are readily available.
Administer ELOXATIN in combination with 5-fluorouracil/leucovorin
every 2 weeks. For advanced disease, treatment is recommended until
disease progression or unacceptable toxicity. For adjuvant use,
treatment is recommended for a total of 6 months (12 cycles):
|Day 1:||ELOXATIN 85 mg/m² intravenous infusion in 250-500 mL 5% Dextrose
injection, USP and leucovorin 200 mg/m² intravenous infusion in 5%
Dextrose Injection, USP both given over 120 minutes at the same
time in separate bags using a Y-line, followed by 5-fluorouracil
400 mg/m² intravenous bolus given over 2-4 minutes, followed by
5-fluorouracil 600 mg/m² intravenous infusion in 500 mL 5% Dextrose
Injection, USP (recommended) as a 22-hour continuous infusion.|
|Day 2:||Leucovorin 200 mg/m² intravenous infusion over 120 minutes,
followed by 5-fluorouracil 400 mg/m² intravenous bolus given over
2-4 minutes, followed by 5-fluorouracil 600 mg/m² intravenous
infusion in 500 mL 5% Dextrose Injection, USP (recommended) as a
22-hour continuous infusion.|