Irinotecan / (free Base) Natural Cancer Cure Drug Medical Materials
|Product Categories:||Camptothecin series;APIs;Natural Anti-cancer Medical Materials and
It's Derivatives;API's;API;chemical reagent;pharmaceutical
intermediate;phytochemical;reference standards from Chinese
medicinal herbs (TCM).;standardized herbal extract;Camptosar,
Irinotecan (Camptosar, Campto) is a drug used for the treatment of
Irinotecan prevents DNA from unwinding by inhibition of
topoisomerase 1. In chemical terms, it is a semisynthetic analogue
of the natural alkaloid camptothecin.
Its main use is in colon cancer, in particular, in combination with
other chemotherapy agents. This includes the regimen FOLFIRI, which
consists of infusional 5-fluorouracil, leucovorin, and irinotecan.
Irinotecan received accelerated approval by the U.S. Food and Drug
Administration (FDA) in 1996 and full approval in 1998. During
development, it was known as CPT-11.
It is on the WHO Model List of Essential Medicines, the most
important medications needed in a basic health system.
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29
cells with IC50 of 15.8 μM and 5.17 μM, respectively
ChEBI: A member of the class of pyranoindolizinoquinolines that is
the carbamate ester obtained by formal condensation of the carboxy
group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic
hydroxy group of (4S)-4,11-diethyl-4,9-dihydro
hydrochloride]quinoline-3,14-dione. Used (in the form of its
hydrochloride salt trihydrate) in combination with fluorouracil and
leucovorin, for the treatment of patients with metastatic
adenocarcino a of the pancreas after disease progression following
gemcitabine-based therapy. It is converted via hydrolysis of the
carbamate linkage to its active metabolite, SN-38, which is ~1000
times more active.